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Ingestion of grapefruit/grapefruit juice is therefore to be avoided while taking nifedipine (see Section 4.2).
Nifedipine is mainly eliminated by metabolism and is a substrate of CYP3A. Inhibitors and inducers of CYP3A can impact the exposure to nifedipine and consequently its desirable and undesirable effects. In vitro and in vivo data indicate that buy adalat cc 60 mg can inhibit the metabolism of drugs that are substrates buy adalat cc 60 mg CYP3A.thereby increasing the exposure to other drugs. Nifedipine is a vasodilator.and coadministration of other drugs affecting blood pressure may result in pharmacodynamic interactions.
In animal studies.nifedipine has been shown to produce embryotoxicity.foetotoxicity and teratogenicity (see section 5.3).
This leaflet answers some common questions about Adalat tablets. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
Nifedipine decreases the elimination of digoxin (Lanoxin) by the kidneys which can increase digoxin blood levels in the blood and give rise to digoxin toxicity. It is important.therefore.to monitor blood levels of digoxin in order to avoid toxicity.
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