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Immunologic. In rare cases.anaphylaxis (including angioedema.face edema and pruritus) has been reported.
One fatal case of possible fentanyl fluconazole interaction was reported. The author judged that the patient died from fentanyl intoxication. Furthermore.in a randomized crossover study with 12 healthy volunteers it was shown that fluconazole delayed diflucan weekly treatment elimination of fentanyl significantly. Elevated fentanyl concentration may lead to respiratory depression.
See Contraindications. Avoid concomitant voriconazole. if needed.monitor closely esp. when given within 24hrs diflucan weekly treatment fluconazole. Caution with amiodarone (esp. with high-dose fluconazole).other drugs metabolized by CYP2C9 and CYP3A4 with a narrow therapeutic window. Potentiates warfarin.oral hypoglycemics.oral midazolam.triazolam.tofacitinib.alfentanil.amitriptyline.nortriptyline.saquinavir.tacrolimus.sirolimus.carbamazepine.methadone.NSAIDs.zidovudine. adjust dose as necessary. May increase levels of phenytoin.theophylline.halofantrine.rifabutin.vinca alkaloids.cyclosporine.fentanyl.calcium channel blockers.losartan. monitor. Concomitant celecoxib. reduce celecoxib dose by half. Increased risk of myopathy/rhabdomyolysis with concomitant HMG-CoA reductase inhibitors. closely monitor. May be potentiated by diuretics. May be antagonized by oral cimetidine.rifampin. Concomitant prednisone. monitor for adrenal cortex insufficiency when fluconazole stopped. Diflucan weekly treatment effects with Vitamin A. Oral contraceptives. see full labeling. Avoid other hepatotoxic drugs.
Older adults may be more sensitive to the side effects of this drug.especially rash.vomiting.diarrhea.and QT prolongation (see above).
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