No significant differences with salmeterol 50 mcg alone or in combination with fluticasone propionate as advair diskus 500 50 were observed on pulse rate and systolic and diastolic blood pressure in a subset of patients with copd who underwent 12-hour serial vital sign measurements after the first dose n 183 and after 12 weeks of therapy n 149 .
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If a previously effective dosage regimen fails to provide adequate improvement in asthma control.the therapeutic regimen should be reevaluated and additional therapeutic options (e.g..replacing the current strength of ADVAIR HFA with a higher strength.adding additional ICS.initiating oral corticosteroids) should be considered.
The problem appears to be the long-acting beta-agonist salmeterol that is one component of Advair.
Physicians should remain vigilant for the possible development of pneumonia in patients with COPD as the clinical features of pneumonia and exacerbations frequently overlap.
Hoarseness.throat irritation.headache.or stomach upset may occur. If any of these effects persist or worsen.tell your doctor promptly.
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